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<p class="MsoNormal" align="right" style="text-align:right"><span style="font-family:"Arial",sans-serif">December 8, 2021<o:p></o:p></span></p>
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<p class="MsoNormal"><span style="font-family:"Arial",sans-serif"><o:p> </o:p></span></p>
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<p class="MsoNormal"><span style="font-family:"Arial",sans-serif">Dear Colleague:<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-family:"Arial",sans-serif"><o:p> </o:p></span></p>
<p class="MsoNormal" style="text-align:justify"><span style="font-family:"Arial",sans-serif">Today, the Centers for Disease Control and Prevention (CDC) published its updated
<i><a href="https://gcc02.safelinks.protection.outlook.com/?url=https%3A%2F%2Ft.emailupdates.cdc.gov%2Fr%2F%3Fid%3Dh581df204%2C1573cb8e%2C1579b38a%26ACSTrackingID%3DUSCDCNPIN_162-DM71567%26ACSTrackingLabel%3DCDC%2520Dear%2520Colleague%253A%2520Updated%2520Clinical%2520Practice%2520Guideline%2520for%2520Preexposure%2520Prophylaxis%2520for%2520HIV%2520Prevention%2520and%2520Clinical%2520Providers%2520Su&data=04%7C01%7CJOSHUA.S.FERRER%40dhsoha.state.or.us%7Cd7fc324d9ce745953fb608d9ba89852c%7C658e63e88d39499c8f4813adc9452f4c%7C0%7C0%7C637745922800885229%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000&sdata=UkgABDRO678Bt62b%2B94MxyyubFb8eXmcUApnb1%2BAsw4%3D&reserved=0">Clinical
Practice Guideline for Preexposure Prophylaxis for HIV Prevention and Clinical Providers Supplement</a></i>. The updated guideline and supplement reflect the latest science and are intended to help physicians effectively prescribe all FDA-approved pre-exposure
prophylaxis (PrEP) medications to patients and increase PrEP use among all people who could benefit.
<o:p></o:p></span></p>
<p class="MsoNormal" style="text-align:justify"><span style="font-family:"Arial",sans-serif"><o:p> </o:p></span></p>
<p class="MsoNormal" style="text-align:justify"><span style="font-family:"Arial",sans-serif">The overall goals of the revisions are to update existing guidance using the current evidence base, incorporate recent and potential FDA actions on PrEP medications,
clarify specific aspects of clinical care, and improve usability and increase implementation of the guideline.
<o:p></o:p></span></p>
<p class="MsoNormal" style="text-align:justify"><span style="font-family:"Arial",sans-serif"><o:p> </o:p></span></p>
<p class="MsoNormal" style="text-align:justify"><b><span style="font-family:"Arial",sans-serif">Key revisions to the guideline include:</span></b><span style="font-family:"Arial",sans-serif"><o:p></o:p></span></p>
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<li class="MsoNormal" style="mso-margin-top-alt:auto;margin-bottom:12.0pt;mso-list:l0 level1 lfo3">
<span style="font-family:"Arial",sans-serif">A new recommendation for providers to inform all sexually active adults and adolescents about PrEP. This is intended to increase awareness of PrEP more broadly.<o:p></o:p></span></li><li class="MsoNormal" style="mso-margin-top-alt:auto;margin-bottom:12.0pt;mso-list:l0 level1 lfo3">
<span style="font-family:"Arial",sans-serif">A recommendation that, in addition to taking a very brief history to identify persons with indications for PrEP, providers prescribe PrEP to anyone who requests it, even if they do not report specific HIV risk behaviors.
This recommendation is intended to make PrEP available to people who may be apprehensive about sharing potentially stigmatized HIV risk behaviors with their provider.<o:p></o:p></span></li><li class="MsoNormal" style="mso-margin-top-alt:auto;margin-bottom:12.0pt;mso-list:l0 level1 lfo3">
<span style="font-family:"Arial",sans-serif">A recommendation for F/TAF (Descovy) as an FDA-approved PrEP option for sexually active men and transgender women at risk of getting HIV, based on recent data showing its effectiveness for these populations.<o:p></o:p></span></li><li class="MsoNormal" style="mso-margin-top-alt:auto;margin-bottom:12.0pt;mso-list:l0 level1 lfo3">
<span style="font-family:"Arial",sans-serif">A new section on prescribing bimonthly intramuscular injections of cabotegravir (CAB) for sexually active men and women who could benefit from PrEP, pending FDA data review and potential regulatory action.<o:p></o:p></span></li><li class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;mso-list:l0 level1 lfo3">
<span style="font-family:"Arial",sans-serif">Updated HIV testing recommendations that incorporate the latest and most effective methods for quickly detecting HIV infection among people using any PrEP medication.<o:p></o:p></span></li></ul>
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<p class="MsoNormal"><span style="font-family:"Arial",sans-serif">Specifically, it includes a recommendation that providers now require the following for people who have taken oral PrEP in the last three months or who have received a CAB injection in the last
12 months:<o:p></o:p></span></p>
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<span style="font-family:"Arial",sans-serif">a positive antigen/antibody test and a detectable HIV-1 RNA test to confirm an HIV infection before transitioning the patient to an HIV treatment regimen; or<o:p></o:p></span></li><li class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;mso-list:l1 level1 lfo6">
<span style="font-family:"Arial",sans-serif">a negative antigen/antibody test and an undetectable HIV-1 RNA test before confirming the absence of an HIV infection to continue prescribing PrEP.<o:p></o:p></span></li></ul>
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<p class="MsoNormal"><span style="font-family:"Arial",sans-serif"><o:p> </o:p></span></p>
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<p class="MsoNormal" style="text-align:justify"><span style="font-family:"Arial",sans-serif">Please note there are no changes to the guideline regarding populations for whom PrEP is recommended nor to the section of the guideline pertaining to recommended daily
dosing regimens for oral PrEP. There are also no changes to the sections of the guideline regarding frequency of HIV and sexually transmitted infection (STI) testing for daily oral PrEP.
<o:p></o:p></span></p>
<p class="MsoNormal" style="text-align:justify"><span style="font-family:"Arial",sans-serif"><o:p> </o:p></span></p>
<p class="MsoNormal" style="text-align:justify"><span style="font-family:"Arial",sans-serif">PrEP is one of the most powerful tools we have to prevent HIV transmission. Expanding access to PrEP will be critical to ending the HIV epidemic in the United States.
CDC is committed to increasing the use of PrEP by funding high-impact HIV prevention programs for health departments and non-clinical and clinical community-based organizations around the country, including through the federal Ending the HIV Epidemic (EHE)
in the U.S. initiative. <o:p></o:p></span></p>
<p class="MsoNormal" style="text-align:justify"><span style="font-family:"Arial",sans-serif"><o:p> </o:p></span></p>
<p class="MsoNormal" style="text-align:justify"><span style="font-family:"Arial",sans-serif">CDC programs are designed to increase PrEP awareness and demand by funding: local organizations to conduct community-based outreach to people who could benefit most
including gay and bisexual men of color, people in the South, Black women, transgender women, and persons who inject drugs; education campaigns that increase awareness and combat stigma associated with PrEP use; and tools such as CDC’s PrEP Locator, which
has information on public and private providers who offer PrEP. <o:p></o:p></span></p>
<p class="MsoNormal" style="text-align:justify"><span style="font-family:"Arial",sans-serif"><o:p> </o:p></span></p>
<p class="MsoNormal" style="text-align:justify"><span style="font-family:"Arial",sans-serif">CDC also aims to increase accessibility of PrEP through healthcare provider training, provider education campaigns, clinical guideline development, and by working with
partners to offer PrEP and related services through primary care clinics, sexually transmitted disease (STD) clinics, TelePrEP services, pharmacies, and school-based health centers.
<o:p></o:p></span></p>
<p class="MsoNormal" style="text-align:justify"><span style="font-family:"Arial",sans-serif"><o:p> </o:p></span></p>
<p class="MsoNormal" style="text-align:justify"><span style="font-family:"Arial",sans-serif">We have a once-in-a-generation opportunity to end the HIV epidemic in the United States, but to do so, we must maximize the use of effective prevention tools, such
as PrEP. As the nation’s leading HIV prevention agency, CDC is committed to working with providers, partners, and communities across the country to increase the implementation of this updated guideline and increase the uptake of PrEP to reach our shared goal
of reducing new HIV infections by 90% by 2030. <o:p></o:p></span></p>
<p class="MsoNormal" style="text-align:justify"><span style="font-family:"Arial",sans-serif"><o:p> </o:p></span></p>
<p class="MsoNormal"><span style="font-family:"Arial",sans-serif"><o:p> </o:p></span></p>
<p class="MsoNormal"><span style="font-family:"Arial",sans-serif">Sincerely, <o:p>
</o:p></span></p>
<p class="MsoNormal"><span style="font-family:"Arial",sans-serif"><o:p> </o:p></span></p>
<p class="MsoNormal"><span style="font-family:"Arial",sans-serif">/Demetre Daskalakis/
<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-family:"Arial",sans-serif"><o:p> </o:p></span></p>
<p class="MsoNormal"><span style="font-family:"Arial",sans-serif">Demetre C. Daskalakis, MD, MPH
<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-family:"Arial",sans-serif">Director <o:p>
</o:p></span></p>
<p class="MsoNormal"><span style="font-family:"Arial",sans-serif">Division of HIV Prevention
<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-family:"Arial",sans-serif">National Center for HIV, Viral Hepatitis, STD, and TB Prevention
<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-family:"Arial",sans-serif">Centers for Disease Control and Prevention
<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-family:"Arial",sans-serif"><a href="https://gcc02.safelinks.protection.outlook.com/?url=http%3A%2F%2Fwww.cdc.gov%2Fhiv&data=04%7C01%7CJOSHUA.S.FERRER%40dhsoha.state.or.us%7Cd7fc324d9ce745953fb608d9ba89852c%7C658e63e88d39499c8f4813adc9452f4c%7C0%7C0%7C637745922800895179%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000&sdata=YhYuVaWufjeFPEG15JwztnpTed8m0U%2BxjR6AANfxwxA%3D&reserved=0">www.cdc.gov/hiv</a>
<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-family:"Arial",sans-serif"> <o:p></o:p></span></p>
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